Modalert containing the active ingredient modafinil, is often referred to as one of the first widely recognized "smart medicines" or nootropics. Originally developed to treat narcolepsy and other sleep disorders, such as sleep apnea and shift work sleep disorder, Modalert gained popularity for its off-label use in enhancing cognitive performance, focus, and wakefulness. It works by altering neurotransmitters in the brain, promoting wakefulness and improving mental clarity without the jittery side effects associated with traditional stimulants. While not the very first substance used for cognitive enhancement, Modalert has been a groundbreaking and widely studied medication in the modern era of nootropics, earning its reputation as a leader in this category.