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To treat narcolepsy, modafinil is often used to increase alertness and decrease daytime drowsiness. At 200 mg per day, individuals usually take it in the morning. This maintains daytime alertness without disturbing sleep. The effective modafinil brand Modalert 200 is often used for this. Depending on tolerance and symptom intensity, smaller or larger dosages may help. Doctors may modify the dose to 100 mg for lesser effects or 400 mg per day for stronger symptom management. Higher dosages may increase adverse effects such headaches, nausea, and sleeplessness and may not enhance effectiveness.

Modalert containing the active ingredient modafinil, is often referred to as one of the first widely recognized "smart medicines" or nootropics. Originally developed to treat narcolepsy and other sleep disorders, such as sleep apnea and shift work sleep disorder, Modalert gained popularity for its off-label use in enhancing cognitive performance, focus, and wakefulness. It works by altering neurotransmitters in the brain, promoting wakefulness and improving mental clarity without the jittery side effects associated with traditional stimulants. While not the very first substance used for cognitive enhancement, Modalert has been a groundbreaking and widely studied medication in the modern era of nootropics, earning its reputation as a leader in this category.